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Atropine (sulfate monohydrate)

CAT: 0804-HY-B0394-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0394-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia[1][2][3][4].
CAS Number
5908-99-6
Product Name Alternative
Tropine tropate (sulfate monohydrate) ; DL-Hyoscyamine (sulfate monohydrate)
UNSPSC
12352005
Hazard Statement
H300, H330
Target
MAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Atropine-sulfate-monohydrate.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
O=[S](O)(O)=O.O=C(C(C1=CC=CC=C1)CO)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.O
Molecular Formula
C17H23NO3.1/2H2O4S.1/2H2O
Molecular Weight
347.43
Precautions
H300, H330
References & Citations
[1]McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33 (3) :373-8.|[2]Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33 (2) :441-57.|[3]Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59 (7) :2778-2791.|[4]Walch L, et, al. Evidence for a M (1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130 (1) :73-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
MAChR4
Citation 01
Cell Discov. 2023 Feb 7;9 (1) :16.|Neuron. 2022 Nov 16;110 (22) :3774-3788.e7.|Arch Oral Biol. 2023 Jan:145:105586.|Can J Physiol Pharmacol. 2020 Oct;98 (10) :725-732.|Cardiovasc Drugs Ther. 2025 Apr 7.|Cell Metab. 2022 Dec 6;34 (12) :1999-2017.e10.|Cell Rep. 2022 Mar 8;38 (10) :110468.|Cell. 2025 Oct 24:S0092-8674 (25) 01129-8.|Eur J Pharmacol. 2024 Sep 3:176954.|Food Chem. 2022 Nov 30:395:133593.|Front Pharmacol. 2020 Jul 31;11:1038.|J Biosci. 2021:46:90.|J Ethnopharmacol. 2024 Jan 30;319 (Pt 2) :117192.|J Hazard Mater. 2024 Mar 5:465:133248.|J Hazard Mater. 2024 Sep 5:479:135690.|J Transl Med. 2025 Jan 23;23 (1) :112.|Research Square Preprint. 2022 Mar.|Research Square Print. 2023 Feb 7.|Research Square Print. December 16th, 2022.

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