Products for Research Use Only
RegisterLogin

Pinacidil (monohydrate)

CAT: 0804-HY-14290A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14290A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil monohydrate enhances K+-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases[1][2].
CAS Number
85371-64-8
Product Name Alternative
P-1134 (monohydrate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Pinacidil_monohydrate.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]O[H].CC(C)(C)C(N/C(NC#N)=N/C1=CC=NC=C1)C
Molecular Formula
C13H21N5O
Molecular Weight
263.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Hamilton TC, et al., Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20 (1) :1-9. |[2]Jung-Ae Kim, et al., Activation of Na+, K+, Cl−-Cotransport Mediates Intracellular Ca2+ Increase and Apoptosis Induced by Pinacidil in HepG2 Human Hepatoblastoma Cells, Biochemical and Biophysical Research Communications, Volume 281, Issue 2, 2001, Pages 511-519, ISSN 0006-291X, |[3]Weston, A.H., et al., In Vitro Studies on the Mode of Action of Pinacidil. Drugs 36 (Suppl 7), 10–28 (1988) . |[4]Ko Zushida, et al ., Effect of diabetes on pinacidil-induced antinociception in mice, European Journal of Pharmacology, Volume 453, Issues 2–3, 2002, Pages 209-215, ISSN 0014-2999.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Bone Res. 2022 Mar 8;10 (1) :25.|Dev Cell. 2022 Jun 6;57 (11) :1383-1399.e7.|Patent. US20240299405A1.|Sci Rep. 2024 Sep 30;14 (1) :22695.

Related Products

CatalogName
HY-14290-01Pinacidil
HY-14290R-01Pinacidil (Standard)
HY-32338-01Tacalcitol (monohydrate)
HY-W303895-01Luteolin (monohydrate)
HY-N1131BTriacetonamine (monohydrate)
HY-B1369-01Imipenem (monohydrate)
HY-13226AGalunisertib (monohydrate)
HY-D0858AMES (monohydrate)
HY-10001A-01Calcipotriol (monohydrate)
HY-10181B-01Dasatinib (monohydrate)

Alternative Products

CatalogName
MBS3842304-01Pinacidil monohydrate
ALX-550-285-M050Pinacidil . monohydrate
A17380-25Pinacidil monohydrate 25mg
A17380-50Pinacidil monohydrate 50mg
A17380-100Pinacidil monohydrate 100mg
A17380-10Pinacidil monohydrate 10mg
A17380-5Pinacidil monohydrate 5mg
NBP2-62756-50mgPinacidil Monohydrate K+ channel activator
A17380-10mM-DPinacidil monohydrate 10mM * 1mL in DMSO
MBS3615008-01Pinacidil

Popular Products