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Pinacidil

CAT: 0804-HY-14290-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14290-01Size:5 mg
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Description
Pinacidil (P-1134) is a potent activator of ATP-sensitive potassium channel. Pinacidil is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil enhances K+-efflux in smooth muscle. Pinacidil has vasorelaxant properties. Pinacidil is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil can be studied in research area such as cardiovascular diseases[1][2].
CAS Number
[60560-33-0]
Product Name Alternative
P-1134
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pinacidil.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C(C)(C)C)N/C(NC1=CC=NC=C1)=N\C#N
Molecular Formula
C13H19N5
Molecular Weight
245.32
Precautions
H315, H319, H320
References & Citations
[1]Hamilton TC, et al., Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20 (1) :1-9. |[2]Jung-Ae Kim, et al., Activation of Na+, K+, Cl−-Cotransport Mediates Intracellular Ca2+ Increase and Apoptosis Induced by Pinacidil in HepG2 Human Hepatoblastoma Cells, Biochemical and Biophysical Research Communications, Volume 281, Issue 2, 2001, Pages 511-519, ISSN 0006-291X, |[3]Weston, A.H., et al., In Vitro Studies on the Mode of Action of Pinacidil. Drugs 36 (Suppl 7), 10–28 (1988) .|[4]Ko Zushida, et al ., Effect of diabetes on pinacidil-induced antinociception in mice, European Journal of Pharmacology, Volume 453, Issues 2–3, 2002, Pages 209-215, ISSN 0014-2999.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Patent. US20240299405A1.|Sci Rep. 2024 Sep 30;14 (1) :22695.|Bone Res. 2022 Mar 8;10 (1) :25.|Dev Cell. 2022 Jun 6;57 (11) :1383-1399.e7.

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