(-) -Indolactam V

• Description:

  (-) -Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

• Product Name Alternative:

  Indolactam V

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  PKC

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_-_-Indolactam-V.html

• Purity:

  98.75

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC (C) [C@@H] (C1=O) N (C) C2=C3C (NC=C3C[C@H] (N1) CO) =CC=C2

• Molecular Formula:

  C17H23N3O2

• Molecular Weight:

  301.38

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-) -indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61 (8) :1415-7.|[2]Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-) -indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66 (7) :1615-7.|[3]Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5 (4) :258-65.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCη; PKCθ

• CAS Number:

  90365-57-4