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(-) -Indolactam V

CAT: 0804-HY-12307-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12307-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
CAS Number
90365-57-4
Product Name Alternative
Indolactam V
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_-_-Indolactam-V.html
Purity
98.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](C1=O)N(C)C2=C3C(NC=C3C[C@H](N1)CO)=CC=C2
Molecular Formula
C17H23N3O2
Molecular Weight
301.38
Precautions
H315, H319, H335
References & Citations
[1]Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-) -indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61 (8) :1415-7.|[2]Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-) -indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66 (7) :1615-7.|[3]Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5 (4) :258-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCη; PKCθ

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