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Gentisuric acid

CAT: 0804-HY-W338852-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W338852-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gentisuric acid, a metabolite of Aspirin , is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316)[2].
CAS Number
25351-24-0
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gentisuric-acid.html
Purity
99.65
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
OC1=CC(C(NCC(O)=O)=O)=C(O)C=C1
Molecular Formula
C9H9NO5
Molecular Weight
211.17
Precautions
H302, H315, H318, H335
References & Citations
[1]DeBlassio JL, et al. Amidation of salicyluric acid and gentisuric acid: a possible role for peptidylglycine alpha-amidating monooxygenase in the metabolism of aspirin. Arch Biochem Biophys. 2000 Nov 1;383 (1) :46-55.|[2]Niikawa M, et al. Suppressive effect of post- or pre-treatment of aspirin metabolite on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster. Biomed Pharmacother. 2007 Feb-Apr;61 (2-3) :113-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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