ZM323881 (hydrochloride)

ZM323881 (hydrochloride)

• CAS Number: 193000-39-4
• UNSPSC Description: ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM.
• Target Antigen: VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/zm323881-hydrochloride.html
• Solubility: DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1.Cl
• Molecular Weight: 411.86
• References & Citations: [1]Whittles CE, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9(6):513-22.|[2]Endo A, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23(2-3):239-54.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported