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ZM323881

CAT: 0804-HY-15467Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15467Size:1 Each
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Description
ZM323881 is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM.
CAS Number
193001-14-8
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zm323881.html
Solubility
10 mM in DMSO
Smiles
CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1
Molecular Formula
C22H18FN3O2
Molecular Weight
375.40
References & Citations
[1]Whittles CE, et al. ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation. 2002 Dec;9 (6) :513-22.|[2]Endo A, et al. Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J Recept Signal Transduct Res. 2003;23 (2-3) :239-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

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