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D-GsMTx4 (TFA)

CAT: 0804-HY-P1410C-01Size: 100 µgDry Ice: NoHazardous: No
CAT#:0804-HY-P1410C-01Size:100 µg
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Description
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410) . D-GsMTx4 TFA inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 TFA inhibits [Ca2+]i elevation. D-GsMTx4 TFA inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 TFA inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 TFA can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis[1][2][3][4].
UNSPSC
12352209
Target
Akt; Calcium Channel; mTOR; PI3K; Piezo Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/d-gsmtx4-tfa.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CSSC[C@@H](C(N[C@H](CCCNC(N)=N)C(N1[C@H](CCC1)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@@H]2CCCCN)=O)=O)=O)=O)=O)NC3=O)C(N[C@H](CC(C)C)C(N[C@H](CCC(O)=O)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@H](CC7=CNC8=CC=CC=C78)C(N[C@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@H](CO)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](CC9=CC=CC=C9)C(N[C@H](CCCCN)C(N[C@@H]%10CC(C)C)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@H](CC(N)=O)C(N%11[C@H](CCC%11)C(N[C@H](CC(N)=O)C(N[C@H](CC(O)=O)C(N[C@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@H]3CSSC[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](CC%12=CC=CC=C%12)C(N[C@H](CO)C(N[C@H](CC%13=CC=CC=C%13)C(N)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O
Molecular Formula
C185H273N49O45S6.xC2HF3O2
Molecular Weight
4095.84 (free base)
References & Citations
[1]Alcaino C, et al. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin) . 2017 May 4;11 (3) :245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13. Erratum for: Addendum to: Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017; 595 (1) :79-91.|[2]Eddy V A, et al. PIEZO2 Signal Transduction Mechanism and Potential Therapeutic Strategies for Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 2025, 211 (Abstracts) : A4722-A4722.|[3]Liu L, et al. Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats. Mol Neurobiol. 2023 Sep;60 (9) :5000-5012.|[4]Jo MJ, et al. Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area. Pain Res Manag. 2024 Sep 27;2024:9179928.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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