D-GsMTx4

• Description:

  D-GsMTx4 is a spider peptide and the D enantiomer of GsMTx4 (HY-P1410) . D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 inhibits [Ca2+]i elevation. D-GsMTx4 inhibits mTOR and PI3K-Akt signaling pathways. D-GsMTx4 inhibits mechanical allodynia and thermal hyperalgesia. D-GsMTx4 can be used in researches of mechanical stress, chronic pain and idiopathic pulmonary fibrosis[1][2][3][4].

• UNSPSC:

  12352209

• Target:

  Akt; Calcium Channel; mTOR; PI3K; Piezo Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-gsmtx4.html

• Purity:

  99.59

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CN)N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N1[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CC4=CC=CC=C4)=O)CO)=O)CC5=CC=CC=C5)=O)CC(N)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(O)=O)=O)CC(N)=O)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC6=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]3CC(C)C)=O)CCCCN)=O)CC7=CC=CC=C7)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CC%12=CC=CC=C%12)=O)CCC(O)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@@H](C(N%13[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]6CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC%13)=O)CCCNC(N)=N)=O

• Molecular Formula:

  C185H273N49O45S6

• Molecular Weight:

  4095.84

• References & Citations:

  [1]Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin) . 2017 May 4;11 (3) :245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13. Erratum for: Addendum to: Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017; 595 (1) :79-91|[2]Eddy V A, et al. PIEZO2 Signal Transduction Mechanism and Potential Therapeutic Strategies for Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 2025, 211 (Abstracts) : A4722-A4722. |[3]Liu L, et al. Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats. Mol Neurobiol. 2023 Sep;60 (9) :5000-5012.|[4]Jo MJ, et al. Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area. Pain Res Manag. 2024 Sep 27;2024:9179928.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported