D-GsMTx4

• UNSPSC Description:

  D-GsMTx4, a spider peptide, is the D-enantiomer of GsMTx4 (HY-P1410). D-GsMTx4 inhibits the mechanosensitive ion channel Piezo2. D-GsMTx4 can be used for research of mechanical stress[1].

• Target Antigen:

  Piezo Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-gsmtx4.html

• Purity:

  99.59

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(CN)N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N1[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CC4=CC=CC=C4)=O)CO)=O)CC5=CC=CC=C5)=O)CC(N)=O)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(O)=O)=O)CC(N)=O)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC6=O)C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]3CC(C)C)=O)CCCCN)=O)CC7=CC=CC=C7)=O)CC(C)C)=O)CCCCN)=O)CO)=O)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)CC%12=CC=CC=C%12)=O)CCC(O)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@@H](C(N%13[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H]6CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC%13)=O)CCCNC(N)=N)=O

• Molecular Weight:

  4095.84

• References & Citations:

  [1]Alcaino C, Knutson K, Gottlieb PA, Farrugia G, Beyder A. Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4. Channels (Austin). 2017 May 4;11(3):245-253. doi: 10.1080/19336950.2017.1279370. Epub 2017 Jan 13. Erratum for: Addendum to: Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2017; 595(1):79-91

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported