PRMT5-IN-31

PRMT5-IN-31

• UNSPSC Description: PRMT5-IN-31 (Compound 3m) is a selective PRMT5 inhibitor (IC50: 0.31 μM). PRMT5-IN-31 up-regulates hnRNP E1 protein level. PRMT5-IN-31 occupies the substrate site of PRMT5 and forms essential interactions with amino acid residues. PRMT5-IN-31 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. PRMT5-IN-31 has high metabolic stability on human liver microsomes (T1/2: 132.4 min)[1].
• Target Antigen: Apoptosis; Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/prmt5-in-31.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O[C@@H](CN1C=CC2=C1C=CC(OC)=C2)CN(C3)CCC4=C3C=CC=C4
• Molecular Weight: 336.43
• References & Citations: [1]Chu WH, et al. Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation. Eur J Med Chem. 2023 Oct 5;258:115625.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported