Dexamethasone phosphate

CAT: 0804-HY-B1829Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1829Size:1 Each
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Description
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research[1].
CAS Number
[312-93-6]
Product Name Alternative
Dexamethasone 21-phosphate
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dexamethasone-phosphate.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(COP(O)(O)=O)=O)=C1
Molecular Formula
C22H30FO8P
Molecular Weight
472.44
Precautions
P261-P280-P302+P352
References & Citations
[1]Fabrizio Bossa, et al. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflamm Bowel Dis. 2013 Aug;19 (9) :1872-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

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