Dexamethasone phosphate

• UNSPSC Description:

  Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a biologically inactive compound which undergoes dephosphorylation by intra-erythrocyte enzymes. The active metabolite, Dexamethasone, is then released into the circulation by simple passive diffusion through cell membranes. Dexamethasone phosphate disodium-encapsulated erythrocyte has the potential for steroid-dependent ulcerative colitis research[1].

• Target Antigen:

  Glucocorticoid Receptor

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/dexamethasone-phosphate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(COP(O)(O)=O)=O)=C1

• Molecular Weight:

  472.44

• References & Citations:

  [1]Fabrizio Bossa, et al. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflamm Bowel Dis. 2013 Aug;19(9):1872-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 4

• CAS Number:

  312-93-6