Dexamethasone oxetanone

Dexamethasone oxetanone

• CAS Number: 4089-36-5
• UNSPSC Description: Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
• Target Antigen: Progesterone Receptor
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Endocrinology
• Assay Protocol: https://www.medchemexpress.com/dexamethasone-oxetanone.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12[C@@]3(C(CO3)=O)[C@@H](C[C@@]1([H])[C@@]4([H])[C@]([C@H](C2)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)C
• Molecular Weight: 374.45
• References & Citations: [1]D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22.|[2]G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 2001 Feb;15(2):255-70.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported