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Dexamethasone oxetanone

CAT: 0804-HY-147220-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147220-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
CAS Number
4089-36-5
Product Name Alternative
Dex-Ox
UNSPSC
12352005
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/dexamethasone-oxetanone.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@@]3(C(CO3)=O)[C@@H](C[C@@]1([H])[C@@]4([H])[C@]([C@H](C2)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)C
Molecular Formula
C22H27FO4
Molecular Weight
374.45
References & Citations
[1]D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25 (3) :315-22.|[2]G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 2001 Feb;15 (2) :255-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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