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(S) -Coriolic acid

CAT: 0804-HY-113884B-01Size: 100 μg (337.33 μM x 1 mL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-113884B-01Size:100 μg (337.33 μM x 1 mL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Coriolic acid (13 (S) -HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S) -Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S) -Coriolic acid induces mitochondrial dysfunction and airway epithelial injury[1][2][3].
CAS Number
29623-28-7
Product Name Alternative
13 (S) -HODE
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Mitochondrial Metabolism; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-coriolic-acid.html
Concentration
337.33 μM * 2.5 mL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/C=C\CCCCCCCC(O)=O
Molecular Formula
C18H32O3
Molecular Weight
296.44
Precautions
H225, H319
References & Citations
[1]Mabalirajan U, et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci Rep. 2013;3:1349.|[2]Ogawa E, et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13 (S) -HODE-mediated activation of the NF-κB signaling pathway. J Invest Dermatol. 2011;131 (3) :604-612.|[3]Yuan H, et al. 15-Lipoxygenases and its metabolites 15 (S) -HETE and 13 (S) -HODE in the development of non-small cell lung cancer. Thorax. 2010;65 (4) :321-326.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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