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(1R) -cis-Bifenthrin

CAT: 0804-HY-B0824ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0824ASize:1 Each
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Description
(1R) -cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R) -cis-Bifenthrin has a significant impact on the motor function of ParKin-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R) -cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R) -cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R) -cis-Bifenthrin has a lower binding energy with transferrin and transferrin receptor 2, showing stronger interactions. The biological effects of (1R) -cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways[1].
CAS Number
439680-76-9
UNSPSC
12352101
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/1r-cis-bifenthrin.html
Smiles
FC(F)(F)/C(Cl)=C/[C@H]1[C@H](C1(C)C)C(OCC2=C(C(C3=CC=CC=C3)=CC=C2)C)=O
Molecular Formula
C23H22ClF3O2
Molecular Weight
422.87
References & Citations
[1]Bifenthrin Caused Parkinson's-Like Symptoms Via Mitochondrial Autophagy and Ferroptosis Pathway Stereoselectively in Parkin-/- Mice and C57BL/6 Mice
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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