Bifenthrin

• Description:

  Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae (LD50=0.15 ng/mg) and C. quinquefasciatus (LD50=0.16 ng/mg) . Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H300, H317, H331, H351, H372, H410

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bifenthrin.html

• Purity:

  99.76

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@H]1C (C) (C) [C@H]1/C=C (Cl) /C (F) (F) F) OCC2=C (C) C (C3=CC=CC=C3) =CC=C2

• Molecular Formula:

  C23H22ClF3O2

• Molecular Weight:

  422.87

• Precautions:

  H300, H317, H331, H351, H372, H410

• References & Citations:

  [1]Hougard JM, et al. Bifenthrin: a useful pyrethroid insecticide for treatment of mosquito nets. J Med Entomol. 2002 May;39 (3) :526-33. |[2]Choi JS, et al. Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes. Toxicol Appl Pharmacol. 2006 Mar 15;211 (3) :233-44.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  82657-04-3