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Sp-TTPαS

CAT: 0804-HY-137613Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-137613Size:1 Each
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Description
Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) hydrolysis inhibitor. Sp-TTPαS competitively inhibits SAMHD1 triphosphohydrolase activity with a Ki value of 46 µM[1].
CAS Number
[83199-32-0]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sp-ttpαs.html
Smiles
O[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO[P@@](OP(OP(O)(O)=O)(O)=O)(S)=O
Molecular Formula
C10H17N2O13P3S
Molecular Weight
498.23
References & Citations
[1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T88752-01Sp-TTP?S
BLG-T003-05Sp-TTP-α-S
T211531-01Sp-TTP?S tetrasodium
BLG-T002-05Rp-TTP-α-S
T 003-05Thymidine- 5'- O- (1- thiotriphosphate), Sp- isomer (Sp-TTP-α-S / Sp-dTTP-α-S), sodium salt
T212252-01Rp-TTP?S tetrasodium
MBS256196-01Thymidine- 5'- O- (1- thiotriphosphate), Sp-isomer (Sp-TTP-alpha-S) / 2'- Deoxythymidine- 5'- O- (1- thiotriphosphate), Sp- isomer (Sp-dTTP-alpha-S)
D8750-01TTP
M14092-01TTP 22
B2565-5TTP-22

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