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Lactupicrin

CAT: 0804-HY-N8290-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N8290-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC50 of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone[1][2][3][4][5].
CAS Number
65725-11-3
Product Name Alternative
Lactucopicrin
UNSPSC
12352005
Hazard Statement
H317
Target
Cholinesterase (ChE) ; LOX-1; NF-κB; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lactupicrin.html
Purity
99.97
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OCC([C@](C1=C2C)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@H](C2)OC(CC(C=C4)=CC=C4O)=O)=CC1=O
Molecular Formula
C23H22O7
Molecular Weight
410.42
Precautions
H317
References & Citations
[1]Wesołowska A, et, al. Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice. J Ethnopharmacol. 2006 Sep 19;107 (2) :254-8.|[2]Li Q, et, al. Terpene Lactucopicrin Limits Macrophage Foam Cell Formation by a Reduction of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Lipid Rafts. Mol Nutr Food Res. 2022 Feb;66 (4) :e2100905. |[3]He L, et al. Lactupicrin Inhibits Cytoplasmic Dynein-Mediated NF-κB Activation in Inflammated Macrophages and Alleviates Atherogenesis in Apolipoprotein E-Deficient Mice. Mol Nutr Food Res. 2021 Feb;65 (4) :e2000989. |[4] Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95 (2-3) :455-7. |[5]Rollinger JM, et al. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Curr Drug Discov Technol. 2005 Sep;2 (3) :185-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
TN4403-01Lactupicrin

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