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Amprolium (hydrochloride)

CAT: 0804-HY-B0937A-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0937A-01Size:1 g
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Description
Amprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption[1][2][3][4].
CAS Number
137-88-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Amprolium-hydrochloride.html
Purity
98.79
Solubility
H2O : ≥ 200 mg/mL
Smiles
CC1=CC=CC=[N+]1CC2=CN=C(CCC)N=C2N.[Cl-].Cl
Molecular Formula
C14H20Cl2N4
Molecular Weight
315.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Iqbal A, et al. Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium against intestinal coccidiosis in goats. J Parasit Dis. 2013 Apr;37 (1) :88-93.|[2]Lindsay DS, et al. Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice. J Parasitol. 1990 Apr;76 (2) :177-9.|[3]Kennedy O Ogolla, et al. Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis. J Vet Med. 2018 Oct 23:2018:5402469.|[4]G Rindi, et al. Action of Amprolium on the thiamine content of rat tissues. J Nutr. 1966 Jun;89 (2) :197-202.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Coccidia

Chemical Information

Amprolium Hydrochloride

See also: Amprolium (broader).

CAS Number137-88-2
PubChem CID8732
IUPAC Name5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine;chloride;hydrochloride
Molecular FormulaC14H20Cl2N4
Molecular Weight315.2
Topological Polar Surface Area55.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity246
SMILES
CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.Cl.[Cl-]
InChI
InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChIKey
PJBQYZZKGNOKNJ-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Amprolium Hydrochloride
CAS: 137-88-2
CID: 8732
Formula: C14H20Cl2N4
MW: 315.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight315.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass314.1065020
Monoisotopic Mass314.1065020
Topological Polar Surface Area55.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity246
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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