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Levodropropizine (Standard)

CAT: 0804-HY-B1895R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1895R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Levodropropizine (Standard) is the analytical standard of Levodropropizine. This product is intended for research and analytical applications. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent[1].
CAS Number
99291-25-5
Product Name Alternative
(S) - (-) -Dropropizine (Standard) ; DF-526 (Standard)
UNSPSC
12352005
Hazard Statement
H302
Target
Histamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Endocrinology; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/levodropropizine-standard.html
Smiles
OC[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1
Molecular Formula
C13H20N2O2
Molecular Weight
236.31
Precautions
P264-P270-P330-P501
References & Citations
[1]Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10 (1) :19.|[2]Luo YL, et al. Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. Inflamm Res. 2013 Dec;62 (12) :1053-61.|[3]Erdogan MA, et al. Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy. Epilepsy Res. 2019 Feb;150:32-37. |[4]Yamawaki I, et al. Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea. Eur J Pharmacol. 1993 Oct 12;243 (1) :1-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Levodropropizine

Levodropropizine is a member of the class of N-arylpiperazines that is N-phenylpiperazine in which the amino hydrogen is replaced by a 2,3-dihydroxypropyl group (the S-enantiomer). A peripherally acting antitussive drug that is used as an alternative to opioids. It has a role as an antitussive. It is a secondary alcohol, a N-alkylpiperazine and a N-arylpiperazine.

CAS Number99291-25-5
PubChem CID65859
IUPAC Name(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
Molecular FormulaC13H20N2O2
Molecular Weight236.31
XLogP0.6
Topological Polar Surface Area46.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity211
SMILES
C1CN(CCN1C[C@@H](CO)O)C2=CC=CC=C2
InChI
InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
InChIKey
PTVWPYVOOKLBCG-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of Levodropropizine
CAS: 99291-25-5
CID: 65859
Formula: C13H20N2O2
MW: 236.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight236.31
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass236.152477885
Monoisotopic Mass236.152477885
Topological Polar Surface Area46.9 Ų
Heavy Atom Count17
Formal Charge0
Complexity211
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CS-O-44010Levodropropizine-D5
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RM-L052509-01Levodropropizine Impurity 9
CGA23740-01Levodropropizine N-oxide
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RM-L052507-01Levodropropizine Impurity 7
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