Nitrendipine-d5

Nitrendipine-d5 is the deuterium labeled Nitrendipine. Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma[1][2][3][4][5][6][7][8][9][10][11].

2469554-26-3

AY-E-5009-d5

12352005

Apoptosis; Calcium Channel; Isotope-Labeled Compounds

Isotope-Labeled Compounds

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Cancer; Neurological Disease; Cardiovascular Disease

99.76

DMSO : 125 mg/mL (ultrasonic)

O=C(C1=C(C)NC(C)=C(C1C2=CC([N+]([O-])=O)=CC=C2)C(OC([2H])([2H])C([2H])([2H])[2H])=O)OC

C18H15D5N2O6

365.39

[1]Rivera I, et al. Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells. Molecular & Cellular Toxicology, 2019, 15: 469-475. |[2]Watson WP, et al. The differential effects of felodipine and nitrendipine on cerebral dihydropyridine binding ex vivo and the ethanol withdrawal syndrome in mice. Br J Pharmacol. 1994 Aug;112 (4) :1017-24. |[3]RABANI, et al. Acute and chronic effects of nitrendipine on naloxone precipitated morphine withdrawal in mice. 2004, 109-114. |[4]Gatch MB. Nitrendipine blocks the nociceptive effects of chronically administered ethanol. Alcohol Clin Exp Res. 2002 Aug;26 (8) :1181-7.|[5]Aktay G, et al. Protective Effect of Nitrendipine on Naphthalene-Induced Oxidative Stress. Eczacilik Fakultesi Dergisi-Gazi Universitesi, 2000, 17 (1) : 19-24. |[6]Michael JR, et al. Nitrendipine attenuates the pulmonary vascular remodeling and right ventricular hypertrophy caused by intermittent hypoxia in rats. Am Rev Respir Dis. 1986 Mar;133 (3) :375-9. |[7]Han P, et al. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin. 2006 Dec;27 (12) :1575-9.|[8]M Bursztyn, et al. Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. Hypertension. 1994 Jun;23 (6 Pt 2) :1051-3.|[9]He-Hui Xie, et al. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens. 2005 Jan;23 (1) :193-201.|[10]S Kazda, et al. Diuretic effect of nitrendipine contributes to its antihypertensive efficacy: a review. J Cardiovasc Pharmacol. 1988;12 Suppl 4:S1-5.|[11]Bellemann, P., et al., [3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes. Arzneimittelforschung, 1981. 31 (12) : p. 2064-7.

Room Temperature

4°C (Powder, protect from light)

Isotope-Labeled Compounds