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Sulforaphane

CAT: 0804-HY-13755-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13755-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression, Sulforaphane protects the heart. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission. Sulforaphane exhibits both anticancer and anti-inflammatory properties[1][2][3][4][5][6].
CAS Number
4478-93-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family; Caspase; HDAC; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Sulforaphane.html
Purity
99.75
Solubility
DMSO : ≥ 62.5 mg/mL
Smiles
O=S(CCCCN=C=S)C
Molecular Formula
C6H11NOS2
Molecular Weight
177.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60 (5) :1426-33.|[2]Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36 (1) :53-64.|[3]Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91 (8) :3147-50.|[4]Chen X, et al. Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of PancreaticCancer via AMPK Dependent Signaling. ell Physiol Biochem. 2018;50 (3) :1201-1215.|[5]De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19 (6) :6975-86.|[6]Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128 (12) :2775-82.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Phase 4
Isoform
Bax; Caspase 3; HDAC

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