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Heptaplatin

CAT: 0804-HY-106588-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-106588-02Size:10 mg
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Description
Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles[1].
CAS Number
146665-77-2
Product Name Alternative
SKI 2053R
UNSPSC
12352300
Hazard Statement
H302-H315-H319-H335
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/heptaplatin.html
Solubility
10 mM in DMSO
Smiles
O=C(O[Pt]([NH2]C1)(O2)[NH2]C[C@@]3([H])OC(O[C@]13[H])C(C)C)CC2=O
Molecular Formula
C11H20N2O6Pt
Molecular Weight
471.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Kim NK, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999;86 (7) :1109-1115.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Eptaplatin

Eptaplatin is a platinum-based compound with alkylating activity. Eptaplatin induces pt-DNA adducts and DNA crosslinks, thereby resulting in an inhibition of cellular proliferation.

CAS Number146665-77-2
PubChem CID119378
IUPAC Name[(4R,5R)-5-(aminomethyl)-2-propan-2-yl-1,3-dioxolan-4-yl]methanamine;platinum(2+);propanedioate
Molecular FormulaC11H20N2O6Pt
Molecular Weight471.37
Topological Polar Surface Area151
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity201
SMILES
CC(C)C1O[C@@H]([C@H](O1)CN)CN.C(C(=O)[O-])C(=O)[O-].[Pt+2]
InChI
InChI=1S/C8H18N2O2.C3H4O4.Pt/c1-5(2)8-11-6(3-9)7(4-10)12-8;4-2(5)1-3(6)7;/h5-8H,3-4,9-10H2,1-2H3;1H2,(H,4,5)(H,6,7);/q;;+2/p-2/t6-,7-;;/m1../s1
InChIKey
XJXKGUZINMNEDK-GPJOBVNKSA-L
Chemical Structure
2D Structure
2D structure of Eptaplatin
CAS: 146665-77-2
CID: 119378
Formula: C11H20N2O6Pt
MW: 471.37
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.37
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass471.096931
Monoisotopic Mass471.096931
Topological Polar Surface Area151 Ų
Heavy Atom Count20
Formal Charge0
Complexity201
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19201803Heptaplatin

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