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Cytochalasin D

CAT: 0804-HY-N6682-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6682-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap[1][2][3][4].
CAS Number
22144-77-0
Product Name Alternative
Zygosporin A; NSC 209835
UNSPSC
12352005
Hazard Statement
H300
Target
Antibiotic; Arp2/3 Complex; YAP
Type
Natural Products
Related Pathways
Anti-infection; Cytoskeleton; Stem Cell/Wnt
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/cytochalasin-d.html
Purity
99.76
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C=C1[C@@H](O)[C@@]2([H])[C@@]3([C@H](OC(C)=O)/C=C/[C@](O)(C)C([C@@H](C)C/C=C/2)=O)[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C
Molecular Formula
C30H37NO6
Molecular Weight
507.62
Precautions
H300
References & Citations
[1]Shoji K, et, al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424 (1) :52-7.|[2]Flanagan MD, et, al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255 (3) :835-8.|[3]Catalano M, et, al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2019 Dec 19;9 (1) :1703244.|[4]Wada K, et, al. Hippo pathway regulation by cell morphology and stress fibers. Development. 2011 Sep;138 (18) :3907-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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