Evatanepag

CAT: 0804-HY-14839-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-14839-02Size:10 mM - 1 mL

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Description

Evatanepag (CP-533536) is a non-prostanoid, potent and selective EP2 receptor agonist. Evatanepag can induce local bone formation in vivo. Evatanepag can be used in the research of fractures, bone defects, asthma[1][2].

CAS Number

223488-57-1

Product Name Alternative

CP-533536 free acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Evatanepag.html

Purity

99.78

Solubility

DMSO : ≥ 32 mg/mL

Smiles

CC(C)(C)C(C=C1)=CC=C1CN(S(C2=CN=CC=C2)(=O)=O)CC3=CC(OCC(O)=O)=CC=C3

Molecular Formula

C25H28N2O5S

Molecular Weight

468.57

Precautions

H302, H315, H319, H335

References & Citations

[1]Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :2075-8.|[2]Judith Plaza, et al. In Vitro and In Vivo Validation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity. Allergy Asthma Immunol Res. 2020 Jul;12 (4) :712-728. |[3]V M Paralkar, et al. An EP2 receptor-selective prostaglandin E2 agonist induces bone healing. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6736-40.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Chemical Information

Evatanepag

Evatanepag is a monocarboxylic acid.

CAS Number	223488-57-1
PubChem CID	9890801
IUPAC Name	2-[3-[[(4-tert-butylphenyl)methyl-pyridin-3-ylsulfonylamino]methyl]phenoxy]acetic acid
Molecular Formula	C25H28N2O5S
Molecular Weight	468.6
XLogP	4.2
Topological Polar Surface Area	105
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Heavy Atom Count	33
Formal Charge	0
Complexity	722

SMILES

CC(C)(C)C1=CC=C(C=C1)CN(CC2=CC(=CC=C2)OCC(=O)O)S(=O)(=O)C3=CN=CC=C3

InChI

InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)

InChIKey

WOHRHWDYFNWPNG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 223488-57-1

CID: 9890801

Formula: C25H28N2O5S

MW: 468.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	468.6
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Exact Mass	468.17189317
Monoisotopic Mass	468.17189317
Topological Polar Surface Area	105 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	722
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
319826	Evatanepag
A21129-100	Evatanepag 100mg
MBS5812300	Evatanepag sodium
A21129-10	Evatanepag 10mg
A21129-5	Evatanepag 5mg
A21129-1	Evatanepag 1mg
MBS131468	Evatanepag? CP533536

Evatanepag

Chemical Information

Alternative Products

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