ML67-33

• Description :

  ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

• CAS Number :

  [1443290-89-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ml67-33.html

• Purity :

  99.28

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1(C)C2=C(C=CC(Cl)=C2)N(CCC3=NN=NN3)C4=CC=C(Cl)C=C14

• Molecular Formula :

  C18H17Cl2N5

• Molecular Weight :

  374.27

• Precautions :

  H315, H319, H320

• References & Citations :

  2P

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported