ML67-33

• Description:

  ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) with EC50s of 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ml67-33.html

• Purity:

  99.28

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1 (C) C2=C (C=CC (Cl) =C2) N (CCC3=NN=NN3) C4=CC=C (Cl) C=C14

• Molecular Formula:

  C18H17Cl2N5

• Molecular Weight:

  374.27

• Precautions:

  H315, H319, H320

• References & Citations:

  2P

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1443290-89-8