Bicuculline methiodide
CAT:
804-HY-103474-06
Size:
10 mM / 1 mL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Bicuculline methiodide
- CAS Number: 40709-69-1
- UNSPSC Description: Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].
- Target Antigen: GABA Receptor
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/bicuculline-methiodide.html
- Purity: 99.24
- Solubility: DMSO : 150 mg/mL (ultrasonic)
- Smiles: C[N+]1([C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O)C.[I-]
- Molecular Weight: 509.29
- References & Citations: [1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231(1):13-6. |[2]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554(7692): 317-322. bioRxiv. 2024 November 26.|Brain Behav Immun. 2019 Nov;82:45-62. |Acta Pharmacol Sin. 2024 Jun 11.|Adv Sci (Weinh). 2024 Dec 16:e2407387.|Biomedicines. 2021, 9(9), 1118.|bioRxiv. 2023 Jul 6.|BMC Immunol. 2022 Nov 25;23(1):58.|Brain Behav Immun. 2023 Jun 5;S0889-1591(23)00141-1.|Cell Rep. 2021 Jul 20;36(3):109398.|Cell Rep. 2023 Nov 17;42(12):113467.|Cell. 2023 Mar 30;186(7):1352-1368.e18.|Clin Exp Hypertens. 2022 Jan 7;1-12.|Immunity. 2024 Mar 12;57(3):495-512.e11.|Int J Mol Sci. 2022, 23(19), 11210.|J Adv Res. 2023 Jun 21;S2090-1232(23)00171-6.|J Agric Food Chem. 2024 Mar 27;72(12):6189-6202.|J Neuroendocrinol. 2020 Jun;32(6):e12876.|J Pain. 2019 May;20(5):577-591. |J Psychiatr Res. 2023 May 17;163:180-194.|Neural Regen Res. 2022 Jan;17(1):178-184.|Neurobiol Dis. 2023 May 12;106155.|Research Square Print. August 24th, 2022.|Research Square Print. September 19th, 2022.|Theranostics. 2022; 12(7):3057-3078.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported