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Kif15-IN-1

CAT: 0804-HY-15948-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15948-01Size:5 mg
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Description
Kif15-IN-1 is an inhibitor of the mitotic Kinesin family member 15 (Kif15), and is used for the research of cellular proliferative diseases.
CAS Number
672926-32-8
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kif15-in-1.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=CC=C1N2)N([C@@H](C(C)C)C(NC3=NC(C)=C(C(OCC)=O)S3)=O)C2=O
Molecular Formula
C20H22N4O5S
Molecular Weight
430.48
References & Citations
[1]Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-12

Chemical Information

Kif15-IN-1
CAS Number672926-32-8
PubChem CID60076300
IUPAC Nameethyl 2-[[(2S)-2-(2,4-dioxo-1H-quinazolin-3-yl)-3-methylbutanoyl]amino]-4-methyl-1,3-thiazole-5-carboxylate
Molecular FormulaC20H22N4O5S
Molecular Weight430.5
XLogP3.2
Topological Polar Surface Area146
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity703
SMILES
CCOC(=O)C1=C(N=C(S1)NC(=O)[C@H](C(C)C)N2C(=O)C3=CC=CC=C3NC2=O)C
InChI
InChI=1S/C20H22N4O5S/c1-5-29-18(27)15-11(4)21-19(30-15)23-16(25)14(10(2)3)24-17(26)12-8-6-7-9-13(12)22-20(24)28/h6-10,14H,5H2,1-4H3,(H,22,28)(H,21,23,25)/t14-/m0/s1
InChIKey
CTQQKICGMSZCJL-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Kif15-IN-1
CAS: 672926-32-8
CID: 60076300
Formula: C20H22N4O5S
MW: 430.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight430.5
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass430.13109099
Monoisotopic Mass430.13109099
Topological Polar Surface Area146 Ų
Heavy Atom Count30
Formal Charge0
Complexity703
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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