TAK-020

TAK-020

• CAS Number: 1627603-21-7
• UNSPSC Description: TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate.
• Target Antigen: Btk
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tak-020.html
• Purity: 99.93
• Solubility: DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C1NNC(C2=CC3=C(C(O[C@@H]4CN(C(C=C)=O)CC4)=N2)C=CC=C3)=N1
• Molecular Weight: 351.36
• References & Citations: [1]Sabat M, et al. Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, by Fragment-Based Drug Design. J Med Chem. 2021 Sep 9;64(17):12893-12902.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Phase 1