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Menthofuran-13C2

CAT: 0804-HY-N9484SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N9484SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Menthofuran-13C2 is 13C labeled Menthol. Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice[1][2][3].
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/menthofuran-13c2.html
Solubility
10 mM in DMSO
Smiles
CC(C1)CCC2=C1O[13CH]=C2[13CH3]
Molecular Formula
C8 13C2H14O
Molecular Weight
152.20
References & Citations
[1]Gordon WP, et al. The metabolism of the abortifacient terpene, (R) - (+) -pulegone, to a proximate toxin, menthofuran. Drug Metab Dispos. 1987 Sep-Oct;15 (5) :589-94. |[2]Mahmoud SS, et al. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase. Proc Natl Acad Sci U S A. 2003 Nov 25;100 (24) :14481-6. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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