Rbin-2

• Description :

  Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].

• UNSPSC :

  12352005

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/rbin-2.html

• Concentration :

  10mM

• Purity :

  98.0

• Solubility :

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C=C(C)CSC1=NN=C2C(NC3=C2C=CC(Br)=C3)=N1

• Molecular Formula :

  C13H11BrN4S

• Molecular Weight :

  335.22

• References & Citations :

  [1]Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167 (2) :512-524.e14.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2032282-97-4]