(S,R,S)-AHPC-O-Ph-PEG1-NH2

(S,R,S)-AHPC-O-Ph-PEG1-NH2

• Alternative Name: VH032-O-Ph-PEG1-NH2
• CAS Number: 2361117-24-8
• UNSPSC Description: (S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-o-ph-peg1-nh2.html
• Purity: 96.97
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: NCCOC1=CC=C(C=C1)OCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O
• Molecular Weight: 623.76
• References & Citations: [1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported