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CUR61414

CAT: 0804-HY-113965-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113965-01Size:5 mg
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Description
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM) . CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].
CAS Number
334998-36-6
Product Name Alternative
CC 122, CC 122 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Hedgehog; Smo
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cur61414.html
Concentration
10mM
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O
Molecular Formula
C31H42N4O5
Molecular Weight
550.69
Precautions
H301
References & Citations
[1]Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100 (8) :4616-21. Epub 2003 Apr 4.|[2]Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1 (2) :10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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GTR19203462-01CUR61414
BUP21711CUR61414 hydrochloride
TBI1392-25MGCUR61414, Hedgehog pathway antagonist
366876-01CUR-61414 (CUR 61414, CUR61414, G-024586)

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