Coagulation Factor VII/F7

Coagulation Factor VII/F7

• Gene Name: [F7]
• NCBI Gene ID: 2155
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.
• Other Gene Names: [F7; F7; SPCA; SPCA]
• Short Name: [VII/F7]
• Other Product Names: [coagulation factor VII isoform a preproprotein; Coagulation factor VII; coagulation factor VII; coagulation factor VII; Proconvertin; Serum prothrombin conversion accelerator]
• NCBI GI Number: 4503645
• NCBI Accession Number: NP_000122.1
• NCBI GB Accession Number: NP_000122.1
• Uniprot Accession Number: P08709