Coagulation Factor VII/F7

• Gene Name:

  [F7]

• NCBI Gene ID:

  2155

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

• Other Gene Names:

  [F7; F7; SPCA; SPCA]

• Short Name:

  [VII/F7]

• Other Product Names:

  [coagulation factor VII isoform a preproprotein; Coagulation factor VII; coagulation factor VII; coagulation factor VII; Proconvertin; Serum prothrombin conversion accelerator]

• NCBI GI Number:

  4503645

• NCBI Accession Number:

  NP_000122.1

• NCBI GB Accession Number:

  NP_000122.1

• Uniprot Accession Number:

  P08709