CD7 (T-Cell Leukemia Marker)

• Gene Name:

  [CD7]

• NCBI Gene ID:

  924

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

• Other Gene Names:

  [CD7; CD7; GP40; TP41; Tp40; LEU-9]

• Short Name:

  [CD7]

• Other Product Names:

  [T-cell antigen CD7; T-cell antigen CD7; T-cell antigen CD7; CD7 molecule; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41; CD_antigen: CD7]

• NCBI GI Number:

  5453613

• NCBI Accession Number:

  NP_006128.1

• NCBI GB Accession Number:

  NP_006128.1

• Uniprot Accession Number:

  P09564