E-Cadherin/CD324 (Intercellular Junction Marker)

E-Cadherin/CD324 (Intercellular Junction Marker)

• Gene Name: [CDH1]
• NCBI Gene ID: 999
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as -catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help of mesothelioma.
• Other Gene Names: [CDH1; CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324; CDHE; UVO; E-cadherin]
• Short Name: [E-Cadherin/CD324]
• Other Product Names: [cadherin-1 isoform 1 preproprotein; Cadherin-1; cadherin-1; cadherin 1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin]
• NCBI GI Number: 4757960
• NCBI Accession Number: NP_004351.1
• NCBI GB Accession Number: NP_004351.1
• Uniprot Accession Number: P12830