E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), 0.2mg/mL

This antibody recognizes a protein of 120-80 kDa, identified as E-cadherin. Cadherins comprise a family of Ca2 -dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as Î2-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

9007-83-4

Arc 1|cadherin 1 type 1 E-cadherin|Cadherin1|CAM 120/80|CD324|CDH1|CDHE|E-Cad/CTF3|E-cadherin|ECAD|Epithelial cadherin|epithelial calcium dependent adhesion protein|Liver cell adhesion molecule (LCAM) |Uvomorulin (UVO)

41116161

Primary and secondary antibodies for multiple methodology immunostaining detection application

CDH1

999

461086

P12830

P12830

CD324|E-Cadherin

Recombinant human full-length E-Cadherin protein

CD324 | E-Cadherin

4A2

Primary

Animal

Animal

Flow (verified) |IF (verified) |IHC, FFPE (verified) |IP (published) |WB (verified)

Cancer, Cell adhesion

LS174T, Raji, HT29, SK-BR3 cells. Prostate or Colon carcinomas.

2 years

0.2 mg/mL

PBS, 0.05% BSA, 0.05% azide

120-80 kDa (Mature) ; 135 kDa (Precursor)

Note: References for this clone sold by other suppliers may be listed for expected applications. Cancer Res (2005) 65: 2. (immunoprecipitation; immunofluorescence)

RT (ND)

Stable at room temperature or 37°C (98°F) for 7 days.

Guaranteed for at least 24 months from date of receipt when stored as recommended

IgG1, kappa

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)