TIM3/HAVCR2/CD366 (Effector T-Cell Marker)

• Gene Name:

  [HAVCR2]

• NCBI Gene ID:

  84868

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+ Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.

• Other Gene Names:

  [HAVCR2; HAVCR2; TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3]

• Short Name:

  [TIM3/HAVCR2/CD366]

• Other Product Names:

  [Hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3]

• NCBI GI Number:

  311033536

• NCBI Accession Number:

  Q8TDQ0.3

• Uniprot Accession Number:

  Q8TDQ0