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TIM3/HAVCR2/CD366 (Effector T-Cell Marker)

CAT: 0544-MBS4381361-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4381361-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[HAVCR2]
NCBI Gene ID
84868
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.
Other Gene Names
[HAVCR2; HAVCR2; TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2; TIM3; TIMD3; HAVcr-2; TIMD-3; TIM-3]
Short Name
[TIM3/HAVCR2/CD366]
Other Product Names
[Hepatitis A virus cellular receptor 2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3]
NCBI GI Number
311033536
NCBI Accession Number
Q8TDQ0.3
Uniprot Accession Number
Q8TDQ0

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Alternative Products

CatalogName
BNUM3113-50TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), 1mg/mL
BNUM2399-50TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), 1mg/mL
BNUB3113-500TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), 0.2mg/mL
BNUB2399-500TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), 0.2mg/mL
36-3422-20Anti-TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) Monoclonal Antibody (Clone: TIM3/3113)
36-3421-100Anti-TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) Monoclonal Antibody (Clone: HAVCR2/192)
BNC883113-500TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF488A conjugate, 0.1mg/mL
BNC743113-100TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF740 conjugate, 0.1mg/mL
BNC403113-500TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF640R conjugate, 0.1mg/mL
BNC473113-500TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (TIM3/3113), CF647 conjugate, 0.1mg/mL

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