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Calpastatin

CAT: 0544-MBS4381359-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4381359-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[CAST]
NCBI Gene ID
831
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpastatin, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.
Other Gene Names
[CAST; CAST; BS-17; PLACK]
Short Name
[Calpastatin]
Other Product Names
[Calpastatin; Calpastatin; calpastatin; calpastatin; Calpain inhibitor; Sperm BS-17 component]
NCBI GI Number
126302556
NCBI Accession Number
P20810.4
Uniprot Accession Number
P20810

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