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Alpha Actinin 4/ACTN4

CAT: 0544-MBS4381356-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4381356-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[ACTN4]
NCBI Gene ID
81
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Other Gene Names
[ACTN4; ACTN4; FSGS; FSGS1; ACTININ-4]
Short Name
[Alpha Actinin 4/ACTN4]
Other Product Names
[Alpha-actinin-4; Alpha-actinin-4; alpha-actinin-4; actinin alpha 4; F-actin cross-linking protein; Non-muscle alpha-actinin 4]
NCBI GI Number
13123943
NCBI Accession Number
O43707.2
Uniprot Accession Number
O43707

ALPHA-ACTININ

Normalized nameALPHA-ACTININ
MyGene LinkClick here

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