Alpha Actinin 4/ACTN4

• Gene Name:

  [ACTN4]

• NCBI Gene ID:

  81

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

• Other Gene Names:

  [ACTN4; ACTN4; FSGS; FSGS1; ACTININ-4]

• Short Name:

  [Alpha Actinin 4/ACTN4]

• Other Product Names:

  [Alpha-actinin-4; Alpha-actinin-4; alpha-actinin-4; actinin alpha 4; F-actin cross-linking protein; Non-muscle alpha-actinin 4]

• NCBI GI Number:

  13123943

• NCBI Accession Number:

  O43707.2

• Uniprot Accession Number:

  O43707