Alpha Actinin 4/ACTN4

Alpha Actinin 4/ACTN4

• Gene Name: [ACTN4]
• NCBI Gene ID: 81
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
• Other Gene Names: [ACTN4; ACTN4; FSGS; FSGS1; ACTININ-4]
• Short Name: [Alpha Actinin 4/ACTN4]
• Other Product Names: [Alpha-actinin-4; Alpha-actinin-4; alpha-actinin-4; actinin alpha 4; F-actin cross-linking protein; Non-muscle alpha-actinin 4]
• NCBI GI Number: 13123943
• NCBI Accession Number: O43707.2
• Uniprot Accession Number: O43707