SIGLEC1/CD169/Sialoadhesin

SIGLEC1/CD169/Sialoadhesin

• Gene Name: [SIGLEC1]
• NCBI Gene ID: 6614
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1,709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells.
• Other Gene Names: [SIGLEC1; SIGLEC1; SN; CD169; SIGLEC-1; SN; Siglec-1]
• Short Name: [SIGLEC1/CD169/Sialoadhesin]
• Other Product Names: [sialoadhesin isoform 1; Sialoadhesin; sialoadhesin; sialic acid binding Ig like lectin 1; Sialic acid-binding Ig-like lectin 1]
• NCBI GI Number: 13489095
• NCBI GB Accession Number: NP_075556.1
• Uniprot Accession Number: Q9BZZ2