SIGLEC1/CD169/Sialoadhesin

• Gene Name:

  [SIGLEC1]

• NCBI Gene ID:

  6614

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1,709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells.

• Other Gene Names:

  [SIGLEC1; SIGLEC1; SN; CD169; SIGLEC-1; SN; Siglec-1]

• Short Name:

  [SIGLEC1/CD169/Sialoadhesin]

• Other Product Names:

  [sialoadhesin isoform 1; Sialoadhesin; sialoadhesin; sialic acid binding Ig like lectin 1; Sialic acid-binding Ig-like lectin 1]

• NCBI GI Number:

  13489095

• NCBI GB Accession Number:

  NP_075556.1

• Uniprot Accession Number:

  Q9BZZ2