Calcineurin A/PPP3CA

• Gene Name:

  [PPP3CA]

• NCBI Gene ID:

  5530

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59kDa catalytic A subunit and a 19kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.

• Other Gene Names:

  [PPP3CA; PPP3CA; CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; ACCIID; CALNA1; IECEE1; CALNA; CNA]

• Short Name:

  [Calcineurin A/PPP3CA]

• Other Product Names:

  [Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; protein phosphatase 3 catalytic subunit alpha; CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform]

• NCBI GI Number:

  1352673

• NCBI Accession Number:

  Q08209.1

• Uniprot Accession Number:

  Q08209