Langerin/CD207 (Marker of Langerhans Cells)

• Gene Name:

  [CD207]

• NCBI Gene ID:

  50489

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

• Other Gene Names:

  [CD207; CD207; CLEC4K; CLEC4K]

• Short Name:

  [Langerin/CD207]

• Other Product Names:

  [C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; CD207 molecule; Langerin; CD_antigen: CD207]

• NCBI GI Number:

  557357745

• NCBI Accession Number:

  NP_056532.4

• NCBI GB Accession Number:

  NP_056532.4

• Uniprot Accession Number:

  Q9UJ71