Langerin/CD207 (Marker of Langerhans Cells)
CAT:
544-MBS4381142-03
Size:
0.1 mg (Without BSA & Azide at 1mg/mL)
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Langerin/CD207 (Marker of Langerhans Cells)
- Gene Name: [CD207]
- NCBI Gene ID: 50489
- Reactivity: Human
- Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required. - Specificity: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
- Other Gene Names: [CD207; CD207; CLEC4K; CLEC4K]
- Short Name: [Langerin/CD207]
- Other Product Names: [C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; C-type lectin domain family 4 member K; CD207 molecule; Langerin; CD_antigen: CD207]
- NCBI GI Number: 557357745
- NCBI Accession Number: NP_056532.4
- NCBI GB Accession Number: NP_056532.4
- Uniprot Accession Number: Q9UJ71