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MTF1

CAT: 0544-MBS4381101-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS4381101-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[MTF1]
NCBI Gene ID
4520
Reactivity
Human
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.
Other Gene Names
[MTF1; MTF1; ZRF; MTF-1]
Short Name
[MTF1]
Other Product Names
[metal regulatory transcription factor 1; Metal regulatory transcription factor 1; metal regulatory transcription factor 1; metal regulatory transcription factor 1; MRE-binding transcription factor; Transcription factor MTF-1]
NCBI GI Number
112790163
NCBI Accession Number
NP_005946.2
NCBI GB Accession Number
NP_005946.2
Uniprot Accession Number
Q14872

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