MTF1

• Gene Name:

  [MTF1]

• NCBI Gene ID:

  4520

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

• Other Gene Names:

  [MTF1; MTF1; ZRF; MTF-1]

• Short Name:

  [MTF1]

• Other Product Names:

  [metal regulatory transcription factor 1; Metal regulatory transcription factor 1; metal regulatory transcription factor 1; metal regulatory transcription factor 1; MRE-binding transcription factor; Transcription factor MTF-1]

• NCBI GI Number:

  112790163

• NCBI Accession Number:

  NP_005946.2

• NCBI GB Accession Number:

  NP_005946.2

• Uniprot Accession Number:

  Q14872