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DNA Ligase 1

CAT: 0544-MBS4381062-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
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CAT#:0544-MBS4381062-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[LIG1]
NCBI Gene ID
3978
Reactivity
Human, Mouse, Rat, Bovine
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
DNA Ligase I maintains the major DNA Ligase activity in proliferating cells by joining Okazaki fragments during lagging strand DNA replication. Human DNA Ligase I also has an essential role in DNA repair pathways, where it catalyzes the formation of phosphodiester bonds between adjacent 5' phosphoryl and 3' hydroxy termini at single breaks in duplex DNA molecules. In addition, DNA Ligase I plays a role in sealing nicks during excision repair. Similar to other DNA ligases, DNA Ligase I is built around a common catalytic core. Increased levels of DNA Ligase I are found in human tumors, as compared to benign tissues, as well as in peripheral blood lymphocytes. Furthermore, DNA Ligase I antisense ODNs syndrome (BS). Individuals with BS either have decreased levels of abnormally thermolabile DNA Ligase I or possess a dimeric form of this enzyme.
Other Gene Names
[LIG1; LIG1]
Short Name
[DNA Ligase 1]
Other Product Names
[DNA ligase 1; DNA ligase 1; DNA ligase 1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1]
NCBI GI Number
118773
NCBI Accession Number
P18858.1
Uniprot Accession Number
P18858

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