HER-4/ERBB4

CAT: 0544-MBS4380869-01Size: 0.02 mg (With BSA & Azide at 0.2mg/mL)Dry Ice: NoHazardous: No
CAT#:0544-MBS4380869-01Size:0.02 mg (With BSA & Azide at 0.2mg/mL)
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Name
[ERBB4]
NCBI Gene ID
2066
Reactivity
Human, Mouse
Predicted to work with Rat, Chicken.
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
Other Gene Names
[ERBB4; ERBB4; HER4; ALS19; p180erbB4; HER4; 4ICD; E4ICD]
Short Name
[HER-4/ERBB4]
Other Product Names
[receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2; Receptor tyrosine-protein kinase erbB-4; receptor tyrosine-protein kinase erbB-4; erb-b2 receptor tyrosine kinase 4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4Cleaved into the following chain:ERBB4 intracellular domain; 4ICD; E4ICD; Alternative name(s):; s80HER4]
NCBI GI Number
110825958
NCBI Accession Number
NP_001036064.1
NCBI GB Accession Number
NP_001036064.1
Uniprot Accession Number
Q15303

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V7741SAF-100UGHER-4 Antibody / ERBB4
BNUM2581-50HER-4 / ERBB4 (ERBB4/2581), 1mg/mL
BNUB2581-100HER-4 / ERBB4 (ERBB4/2581), 0.2mg/mL
36-2237-20Anti-HER-4 / ERBB4 Monoclonal Antibody (Clone: ERBB4/2581)
BNC682581-100HER-4 / ERBB4 (ERBB4/2581), CF568 conjugate, 0.1mg/mL
BNC402581-500HER-4 / ERBB4 (ERBB4/2581), CF640R conjugate, 0.1mg/mL
BNC742581-100HER-4 / ERBB4 (ERBB4/2581), CF740 conjugate, 0.1mg/mL
BNC882581-500HER-4 / ERBB4 (ERBB4/2581), CF488A conjugate, 0.1mg/mL
BNCB2581-100HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL
BNC042581-100HER-4 / ERBB4 (ERBB4/2581), CF405S conjugate, 0.1mg/mL

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