Cathepsin D (Tumor Marker)

• Gene Name:

  [CTSD]

• NCBI Gene ID:

  1509

• Reactivity:

  Human

• Storage Conditions:

  Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Specificity:

  Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

• Other Gene Names:

  [CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD]

• Short Name:

  [Cathepsin D]

• Other Product Names:

  [cathepsin D preproprotein; Cathepsin D; cathepsin D; cathepsin D]

• NCBI GI Number:

  4503143

• NCBI Accession Number:

  NP_001900.1

• NCBI GB Accession Number:

  NP_001900.1

• Uniprot Accession Number:

  P07339